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Article

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

28 May 2013

Abstract excerpt

BACKGROUND: DNA methylation is of pivotal importance during development. Previous genome-wide studies identified numerous differentially methylated regions upon differentiation of stem cells, many of them associated with transcriptional start sites. RESULTS: We present the first genome-wide, single-base-resolution view into DNA methylation dynamics during differentiation of a mammalian epithelial stem cell: the...

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PMID: 23714178
DOI: 10.1186/gb-2013-14-5-r50

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