Article

2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticles

2026-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Ionizable lipid nanoparticles (iLNPs) are powerful platforms for mRNA-based vaccines and immunotherapies; however, their intrinsic liver tropism compromises both safety and efficacy. Off-target hepatic protein expression from delivered mRNA raises safety concerns, and hepatic clearance limits efficient iLNP delivery to target organs. In this study, we address these challenges in mouse models by...

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Literature Corpus work: 9f966feb-1240-53fd-902f-da137026ec6f
DOI: 10.64898/2026.04.29.721537

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2-arm-PEG-oligocations transiently shield the liver sinusoids to mitigate off-target hepatic expression of mRNA lipid nanoparticlesDOI 10.64898/2026.04.29.721537Read

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