Article

Extrahepatic, cell-specific delivery of LNPs through competitive inhibition of ApoE-mediated uptake

2026-06-02

Abstract excerpt

Targeted lipid nanoparticles (LNPs) for extrahepatic drug delivery are limited by apolipoprotein E (ApoE)-mediated hepatic accumulation. We developed NanoPilot ™ , a modular fusion protein platform comprising antibodies and anchors blocking the low density lipoprotein receptor (LDLR) ApoE binding site, to block LNP liver uptake and redirect to target cells. NanoPilot can be applied to preformulated LNPs in 10 min...

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Literature Corpus work: a807d6b1-9b54-5107-9179-e51b61322153
DOI: 10.64898/2026.05.29.727812

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