Article

Poly(acrylamido) PEG-alternatives Enhance mRNA-LNP Efficacy in Immune Cells and Evade Anti-PEG Antibodies after Repeated Dosing

2026-02-28

Abstract excerpt

Following the successes of the messenger RNA (mRNA) lipid nanoparticle (LNP) vaccines during the COVID-19 pandemic, mRNA-LNPs are being explored for many critical disease indications including infectious disease vaccination, cancer immunotherapies, and protein replacement therapies. LNPs require a polymer coating to provide stability in storage, and to minimise clearance from the body by reducing protein adsorptio...

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Literature Corpus work: 208e3666-badd-5adb-874e-ae6b8b3414b7
DOI: 10.64898/2026.02.26.708093

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