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Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and <i>in vivo</i> CAR T-cell engineering

2026-01-26

Abstract excerpt

Targeted lipid nanoparticles (tLNPs) enable efficient mRNA delivery to T cells, allowing for in situ generation of chimeric antigen receptor (CAR) T cells without ex vivo manipulation. This strategy has shown promising therapeutical efficacy in preclinical studies of cardiac fibrosis, cancer, and autoimmune diseases. While multiple T-cell surface receptors have been targeted across studies for tLNP-mediated in...

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Literature Corpus work
e393fa3b-7d82-50f9-8d4c-76d4a75167c9
DOI
10.64898/2026.01.23.701374
Open publication

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Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and <i>in vivo</i> CAR T-cell engineeringDOI 10.64898/2026.01.23.701374
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