Article

Gain of chromosome region 1q31.3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes

2023-12-12

Abstract excerpt

<h4>SUMMARY</h4> hPSCs can acquire chromosomal aberrations such as copy number variations during prolonged maintenance in vitro , conferring growth advantages. However, the effect of these culture-acquired mutations on the phenotypes of the differentiated hPSCs is largely unstudied. Here, we identified mosaicism in a hPSC line in which some cells showed a gain of chromosome 1q31.3. We subcloned the wild-type and...

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Literature Corpus work: 01428fe7-ba91-5a8e-85b6-5721ed2ab597
DOI: 10.1101/2023.12.11.571144

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