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Article

A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes.

PloS one - 23 Apr 2010

Hovatta Outi, Jaconi Marisa, Töhönen Virpi, Béna Frédérique, Gimelli Stefania, Bosman Alexis, Holm Frida, Wyder Stefan, Zdobnov Evgeny M, Irion Olivier, Andrews Peter W, Antonarakis Stylianos E, Zucchelli Marco, Kere Juha, Feki Anis

Abstract excerpt

The first Swiss human embryonic stem cell (hESC) line, CH-ES1, has shown features of a malignant cell line. It originated from the only single blastomere that survived cryopreservation of an embryo, and it more closely resembles teratocarcinoma lines than other hESC lines with respect to its abnormal karyotype and its formation of invasive tumors when injected into SCID mice. The aim of this study was to...

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Identifiers

PMID: 20428235
DOI: 10.1371/journal.pone.0010263
PMCID: PMC2859053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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