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Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression.

Seminars in cancer biology - 1 Jun 2022

Xuan Botai, Ghosh Deepraj, Dawson Michelle R

Abstract excerpt

Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug resistant cancers. The chromosomal duplication conferred by their aneuploidy gives rise to DNA damage resistance and complex tumor cell karyotypes, a driving factor in chemotherapy resistance and disease relapse. Furthermore, PGCCs also exhibit key cytoskeletal...

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PMID: 33992783
DOI: 10.1016/j.semcancer.2021.05.014

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