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Article

Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancer

15 Jun 2022

Abstract excerpt

The metastatic progression of cancer remains a major issue in patient treatment. However, the molecular and cellular mechanisms underlying this process remain unclear. Here, we use primary explants and organoids from patients harboring mucinous colorectal carcinoma (MUC CRC), a poor-prognosis histological form of digestive cancer, to study the architecture, invasive behavior and chemoresistance of tumor cell...

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PMID: 35703098
DOI: 10.1242/jcs.259256

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