Article

Single-cell spatial multiomics identifies <i>POSTN</i> <sup>+</sup> CAFs mediating chemoradiotherapy resistance in rectal cancer

2026-05-05

Abstract excerpt

Neoadjuvant chemoradiotherapy (CRT) is standard for locally advanced rectal cancer (LARC), yet many patients retain residual disease. To resolve CRT-associated remodeling of the tumor microenvironment, we generated a multimodal spatial atlas from serial sections of paired pretreatment and post-treatment specimens from 24 patients using Xenium single-cell spatial transcriptomics and PhenoCycler multiplex proteomics...

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Literature Corpus work: 84198896-d0f2-5dc8-a48f-44c566b0e259
DOI: 10.64898/2026.04.30.721803

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