Article

Single-cell and Spatial Transcriptomic Mapping Reveals MSEC-myoCAF Interactions Driving Lymph Node Metastasis in Colorectal Cancer

2025-06-05

Abstract excerpt

<title>Abstract</title> <p>Lymph node metastasis (LNM) is a major determinant of poor prognosis in colorectal cancer (CRC), yet the cellular and spatial mechanisms driving metastatic initiation remain poorly defined. Here, we performed integrative single-cell RNA sequencing (scRNA-seq; 84,735 cells) and spatial transcriptomics (ST; 20,859 spots) on paired primary tumors and metastatic lymph nodes from five CRC pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c0d423d-cde0-5f3a-9b3e-17792a7beaa7
DOI: 10.21203/rs.3.rs-6803290/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell and Spatial Transcriptomic Mapping Reveals MSEC-myoCAF Interactions Driving Lymph Node Metastasis in Colorectal CancerDOI 10.21203/rs.3.rs-6803290/v1Read

Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancerSemantic proximity Read

Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasisSemantic proximity Read

Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancerSemantic proximity Read

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity Read

Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in oesophageal squamous cell carcinomaSemantic proximity Read

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node MetastasisSemantic proximity Read

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblastsSemantic proximity Read

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancerSemantic proximity Read

Single‐cell RNA sequencing reveals the heterogeneity of MYH11 + tumour‐associated fibroblasts between left‐sided and right‐sided colorectal cancerSemantic proximity Read

Redefining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read

Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRCSemantic proximity Read

Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in esophageal squamous cell carcinomaSemantic proximity Read