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Prognostic stratification by LGR5 expression identifies surface-accessible, structurally ligandable and condensate-forming targets in colorectal cancer

2026-08-27

Abstract excerpt

<h4>Background</h4> LGR5 marks colorectal cancer stem cells and is associated with poor outcome, but its expression on normal intestinal stem cells has constrained direct therapeutic targeting, and the molecular landscape of LGR5-high tumors remains incompletely defined. A transcriptional signature is not itself a set of drug targets: its constituent genes differ in whether and how they can be engaged pharmacolog...

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Literature Corpus work: 6b18e5e8-2bf2-5a4d-8f71-44e1203414b2
DOI: 10.64898/2026.08.26.747295

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