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Article

Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy.

Experimental neurology - 1 Sept 2016

Hu Qidi, Ren Xiangpeng, Liu Ya, Li Zhihui, Zhang Liping, Chen Xingjun, He Chaoxiang, Chen Jiang-Fan

Abstract excerpt

Synucleinopathy is characterized by abnormal accumulation of misfolded α-synuclein (α-Syn)-positive cytoplasmic inclusions and by neurodegeneration and cognitive impairments, but the pathogenesis mechanism of synucleinopathy remains to be defined. Using a transmission model of synucleinopathy by intracerebral injection of preformed A53T α-Syn fibrils, we investigated whether aberrant adenosine A2A receptor (A2AR)...

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PMID: 27342081
DOI: 10.1016/j.expneurol.2016.05.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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