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Article

Analysis of in vivo turnover of tau in a mouse model of tauopathy.

Molecular neurodegeneration - 26 Oct 2015

Yamada Kaoru, Patel Tirth K, Hochgräfe Katja, Mahan Thomas E, Jiang Hong, Stewart Floy R, Mandelkow Eva-Maria, Holtzman David M

Abstract excerpt

BACKGROUND: Intracellular accumulation of tau as neurofibrillary tangles (NFTs) is the hallmark of Alzheimer's disease (AD) as well as in other tauopathies. Tau is present not only in the cytoplasm but also in the extracellular space such as cerebrospinal fluid (CSF) and brain interstitial fluid (ISF). Although clearance is one critical parameter leading to such intracellular/extracellular tau accumulation, in...

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Identifiers

PMID: 26502977
DOI: 10.1186/s13024-015-0052-5
PMCID: PMC4621881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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