Article

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

2020-10-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins <italic>in vitro</italic> and <italic>in vivo</italic>. Previously<italic>,</italic> we evaluated the effect of CLR01 in the 3×Tg mouse model of Alzheimer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 416f3de3-0e5f-5d55-bc0f-63314612cc05
DOI: 10.21203/rs.3.rs-88943/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic miceDOI 10.21203/rs.3.rs-88943/v1Read

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALSSemantic proximity Read

Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors in mouse models of tauopathySemantic proximity Read

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy miceSemantic proximity Read

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s diseaseSemantic proximity Read

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Semantic proximity Read

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.Semantic proximity Read

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential InhibitorsSemantic proximity Read

Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model.Semantic proximity Read

TREM2 limits progression of deficits and spreading of tau pathology in miceSemantic proximity Read

Proteostasis as a fundamental principle of Tau immunotherapySemantic proximity Read

Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoformsSemantic proximity Read

Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila.Semantic proximity Read