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Article

Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation.

Molecular cell - 5 Jan 2017

Alexandrov Andrei, Shu Mei-Di, Steitz Joan A

Abstract excerpt

Nonsense-mediated decay (NMD) degrades mRNAs containing a premature termination codon (PTC). PTCs are a frequent cause of human genetic diseases, and the NMD pathway is known to modulate disease severity. Since partial NMD attenuation can potentially enhance nonsense suppression therapies, better definition of human-specific NMD is required. However, the majority of NMD factors were first discovered in model...

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Identifiers

PMID: 28017590
DOI: 10.1016/j.molcel.2016.11.032
PMCID: PMC5301997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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