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PDE9 Inhibition Activates PPARα to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

2021-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Central obesity with cardiometabolic syndrome (CMS) is a major global contributor to human disease, and effective therapies are needed. Here, we show inhibiting cyclic-GMP selective phosphodiesterase-9A (PDE9-I) suppresses established diet-induced obesity and CMS in ovariectomized female and male mice. PDE9-I reduces abdominal, hepatic, and myocardial fat accumulation, stimulates mitochondrial a...

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Literature Corpus work
9f1b4c78-9473-530a-ba68-6fc4ba972a24
DOI
10.1101/2021.02.02.429442
Open publication

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PDE9 Inhibition Activates PPARα to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic SyndromeDOI 10.1101/2021.02.02.429442
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