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Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice

2021-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Obesity in pregnant women causes fetal cardiac dysfunction and increases offspring cardiovascular disease risk but its effect on myocardial metabolism is unknown. We hypothesised that maternal obesity alters fetal cardiac expression of metabolism-related genes and shifts offspring myocardial substrate preference from glucose towards lipids. Female mice were fed control or obesogenic diets before...

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Literature Corpus work
04d16f8d-7fba-50eb-bc10-665572c787ec
DOI
10.1101/2021.09.15.460457
Open publication

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