Article

Chronic Unpredictable Stress Drives Non-pathological, Adaptive Metabolic Hormone Reprogramming with Reduced Insulin Resistance Linked to Depressive-like Behaviors

2026-02-07

Abstract excerpt

Major Depressive Disorder (MDD) is increasingly conceptualized as a neuroimmune-metabolic-oxidative stress (NIMETOX) condition, partly driven by environmental stressors. While new antidepressant strategies have emerged to target NIMETOX pathways, the mechanism by which chronic stress reshapes metabolic regulation-particularly in the absence of clinically overt metabolic disease-remain poorly understood. Using a 6-...

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Literature Corpus work: 665fadfb-800a-5e97-91e5-49fcaccd2e4c
DOI: 10.64898/2026.02.05.703942

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