Article

Epigenomics and Transcriptomics of Systemic Sclerosis CD4+ T cells reveal Long Range Dysregulation of Key Inflammatory Pathways mediated by disease-associated Susceptibility Loci

2020-03-17

Abstract excerpt

<h4>ABSTRACT</h4> System sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. In this study, we obtained DNA methylation and expression profiles of CD4+ T cells from 48 SSc patients and 16 healthy controls. Consequently, we identified 9112...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f13da49-b18c-5394-b539-235f560f99f8
DOI: 10.1101/2020.03.14.20036061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenomics and Transcriptomics of Systemic Sclerosis CD4+ T cells reveal Long Range Dysregulation of Key Inflammatory Pathways mediated by disease-associated Susceptibility LociDOI 10.1101/2020.03.14.20036061Read

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.Semantic proximity Read

Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis riskSemantic proximity Read

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesisSemantic proximity Read

Identification of Mechanisms by Which Genetic Susceptibility Loci Influence Systemic Sclerosis Risk Using Functional Genomics in Primary T Cells and Monocytes.Semantic proximity Read

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsetsSemantic proximity Read

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.Semantic proximity Read

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis.Semantic proximity Read

Unfolding the pathogenesis of scleroderma through genomics and epigenomics.Semantic proximity Read

Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes.Semantic proximity Read

Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory GenesSemantic proximity Read

Differential DNA methylation landscape in skin fibroblasts from African Americans with systemic sclerosisSemantic proximity Read

Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.Semantic proximity Read