Article
Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.
Genome medicine - 25 Sept 2020
Li Tianlu, Ortiz-Fernández Lourdes, Andrés-León Eduardo, Ciudad Laura, Javierre Biola M, López-Isac Elena, Guillén-Del-Castillo Alfredo, Simeón-Aznar Carmen Pilar, Ballestar Esteban, Martin Javier
Abstract excerpt
BACKGROUND: Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. METHODS: DNA samples exacted from CD4+ T cells of 48 SSc patients and 16 healthy controls were hybridized on MethylationEPIC BeadChip array. In parallel, gene...
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