Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis.

BMC medical genomics - 24 Oct 2019

Lu Tianyuan, Klein Kathleen Oros, Colmegna Inés, Lora Maximilien, Greenwood Celia M T, Hudson Marie

Abstract excerpt

BACKGROUND: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that both genetic susceptibilities and changes in DNA methylation influence pivotal biological pathways and thereby contribute to the disease. The role of DNA methylation in SSc has not been fully elucidated, because existing investigations of DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pilot Projects

Share to Scleroderma, Systemic

Share to Sulfites

Share to Whole Genome Sequencing

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 31651337
DOI: 10.1186/s12920-019-0602-8
PMCID: PMC6813992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis.PMID 31651337Read ↗

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesisSemantic proximity Read ↗

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsetsSemantic proximity Read ↗

Differential DNA methylation landscape in skin fibroblasts from African Americans with systemic sclerosisSemantic proximity Read ↗

Epigenomics and Transcriptomics of Systemic Sclerosis CD4+ T cells reveal Long Range Dysregulation of Key Inflammatory Pathways mediated by disease-associated Susceptibility LociSemantic proximity Read ↗

Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis.Semantic proximity Read ↗

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.Semantic proximity Read ↗

Unfolding the pathogenesis of scleroderma through genomics and epigenomics.Semantic proximity Read ↗

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis.Semantic proximity Read ↗

Epigenetics: The Future Direction in Systemic Sclerosis.Semantic proximity Read ↗

Genetic and epigenetic abnormalities in systemic sclerosis.Semantic proximity Read ↗

Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndromeSemantic proximity Read ↗

Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.