Article
Unfolding the pathogenesis of scleroderma through genomics and epigenomics.
Journal of autoimmunity - 1 Sept 2017
Tsou Pei-Suen, Sawalha Amr H
Abstract excerpt
With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by immune activation, vascular complications, and excessive fibrosis in internal organs. Genetic studies, including candidate gene association studies, genome-wide association studies, and whole-exome sequencing have supported the notion that while genetic susceptibility to SSc appears to be modest, SSc patients are genetically...
Topics
- Epigenomics
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Genomics
- HLA Antigens
- Humans
- Interferon Regulatory Factors
- Polymorphism, Genetic
- STAT4 Transcription Factor
- Scleroderma, Systemic
- Signal Transduction