Article

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

2023-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the acidic intrinsically disordered domain of the host transcription regulator ANP32A, a deletion that restricts FluPol activity in mammalian cells. The function of ANP32A in the replication transcri...

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Literature Corpus work: 2e4092a8-931d-5ee8-b6a9-543bf27449ea
DOI: 10.1101/2023.07.08.548184

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