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Article

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

Journal of virology - 1 Nov 2016

DeDiego Marta L, Nogales Aitor, Lambert-Emo Kris, Martinez-Sobrido Luis, Topham David J

Abstract excerpt

Influenza NS1 protein is the main viral protein counteracting host innate immune responses, allowing the virus to efficiently replicate in interferon (IFN)-competent systems. In this study, we analyzed NS1 protein variability within influenza A (IAV) H3N2 viruses infecting humans during the 2012-2013 season. We also evaluated the impact of the mutations on the ability of NS1 proteins to inhibit host innate immune...

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Source

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Identifiers

PMID: 27535054
DOI: 10.1128/JVI.01039-16
PMCID: PMC5068522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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