Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones

Abstract excerpt

The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface.Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones.Particularly noteworthy, we observe that the Pro283 nucleoprotein variant, which (1) is conserved across human influenza strains, (2) confers resistance to the...

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