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Chromatin Priming Index Reveals Compartmentalized Epigenetic Programming in Tuberculosis: A Computational Re-Analysis of Public Single-Cell Data

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>Background Tuberculosis treatment failure affects 5–10% of drug-susceptible patients, yet biomarkers predicting this outcome remain elusive. Single-cell multiomics data from TB patients offer an opportunity to explore epigenetic determinants of host-pathogen interactions. Methods We developed the Chromatin Priming Index (CPI), a computational metric quantifying the proportion of diffe...

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Literature Corpus work
9edf2ff4-8dcb-51bd-a3cf-aa3c661bb3a5
DOI
10.21203/rs.3.rs-8573127/v1
Open publication

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Chromatin Priming Index Reveals Compartmentalized Epigenetic Programming in Tuberculosis: A Computational Re-Analysis of Public Single-Cell DataDOI 10.21203/rs.3.rs-8573127/v1
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