Article

Dissecting epigenome dynamics in human immune cells upon viral and chemical exposure by multimodal single-cell profiling

2025-09-11

Abstract excerpt

Environmental and pathogen exposure can lead to profound remodeling of the gene-regulatory landscape across human immune cell populations. Here, we present a single-nucleus chromatin accessibility atlas of human immune cells comprising 271,299 cells and 319,420 candidate regulatory elements from individuals exposed to HIV-1, COVID-19, Influenza virus, organophosphates, as well as healthy controls. Our longitudinal...

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Identifiers and source

Literature Corpus work: 825073ee-6266-516a-b1ca-e4e30618f29a
DOI: 10.1101/2025.09.09.675101

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