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Epigenetic impairment and blunted transcriptional response to <i>Mycobacterium tuberculosis</i> of alveolar macrophages from persons living with HIV

2021-01-29

Abstract excerpt

Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is often the result of recent infection with Mycobacterium tuberculosis ( Mtb ) followed by rapid progression to disease. Alveolar macrophages (AM) are the first cells of the innate immune system that engage Mtb , but how HIV and antiretroviral therapy (ART) impact on the anti-mycobacterial response of AM is not known. To...

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Identifiers and source

Literature Corpus work
0299d464-feff-537d-adc5-77693904b6bc
DOI
10.1101/2021.01.26.21250318
Open publication

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Epigenetic impairment and blunted transcriptional response to <i>Mycobacterium tuberculosis</i> of alveolar macrophages from persons living with HIVDOI 10.1101/2021.01.26.21250318
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