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Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature

1 Jan 2023

Abstract excerpt

(Mtb), remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms and disables key antibacterial response pathways, many of which are regulated by epigenetic mechanisms that control the accessibility of chromatin to the transcriptional machinery. Recent reports suggest that host phosphatases, such as PPM1A, contribute to regulating chromatin accessibility during bacterial infections....

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PMID: 36820061
DOI: 10.1093/femsml/uqad006

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