Article

In vivo metabolomic study uncovers distinct metabolic phenotypes of host tissues and predicts oxidative state of acute myeloid leukemia

2021-07-20

Abstract excerpt

<title>Abstract</title> <p>Background Metabolic adaptation is a hallmark of cancer including acute myeloid leukemia (AML). Tumor microenvironment is also described as an essential support of leukemic metabolism. We explored how systemic and tissue metabolism was rewired in leukemia-bearing mice and upon chemotherapy. Methods Using AML cell line- and primary patient-derived xenograft models, we developed <italic...

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Literature Corpus work: 9e9b9222-7191-5c17-948d-62c4ac66e61c
DOI: 10.21203/rs.3.rs-719532/v1

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