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Article

Distinct Metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood Acute Myeloid Leukemia.

Scientific reports - 3 Apr 2018

Stockard Bradley, Garrett Timothy, Guingab-Cagmat Joy, Meshinchi Soheil, Lamba Jatinder

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease with dismal response warranting the need for enhancing our understanding of AML biology. One prognostic feature associated with inferior response is the presence of activating mutations in FMS-like tyrosine kinase 3 (FLT3) especially occurrence of internal tandem duplication (FLT3-ITD). Although poorly understood, differential metabolic and signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29615816
DOI: 10.1038/s41598-018-23863-9
PMCID: PMC5882915

Genes

FLT3

Provenance

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