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Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche

29 Jun 2022

Abstract excerpt

Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML predominantly affects older people and outcomes, particularly in this difficult to treat population remain poor, in part due to inadequate response to therapy, and treatment toxicity. Normal haematopoiesis is supported by numerous support cells within the BM...

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PMID: 35847950
DOI: 10.3389/fonc.2022.924567

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