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Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets

22 Dec 2022

Abstract excerpt

Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often genotype specific, with associated changes in epigenetic and functional factors resulting in the downstream upregulation or facilitation of oncogenic pathways. Targeting abnormal or disease-sustaining metabolic activities in AML...

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PMID: 36548959
DOI: 10.1182/blood.2022018092

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