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Article

Metabolomic profile of acute myeloid leukaemia parallels of prognosis and response to therapy.

Scientific reports - 9 Dec 2023

Bolkun Lukasz, Pienkowski Tomasz, Sieminska Julia, Godzien Joanna, Pietrowska Karolina, Kłoczko Janusz, Wierzbowska Agnieszka, Moniuszko Marcin, Ratajczak Mariusz, Kretowski Adam, Ciborowski Michal

Abstract excerpt

The heterogeneity of acute myeloid leukemia (AML), a complex hematological malignancy, is caused by mutations in myeloid cells affecting their differentiation and proliferation. Thus, various cytogenetic alterations in AML cells may be characterized by a unique metabolome and require different treatment approaches. In this study, we performed untargeted metabolomics to assess metabolomics differences between AML...

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Identifiers

PMID: 38071228
DOI: 10.1038/s41598-023-48970-0
PMCID: PMC10710498

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