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Article

The metabolic reprogramming in acute myeloid leukemia patients depends on their genotype and is a prognostic marker.

Blood advances - 12 Jan 2021

Lo Presti Caroline, Fauvelle Florence, Jacob Marie-Christine, Mondet Julie, Mossuz Pascal

Abstract excerpt

Leukemic cells display some alterations in metabolic pathways, which play a role in leukemogenesis and in patients' prognosis. To evaluate the characteristics and the impact of this metabolic reprogramming, we explore the bone marrow samples from 54 de novo acute myeloid leukemia (AML) patients, using an untargeted metabolomics approach based on proton high-resolution magic angle spinning-nuclear magnetic...

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Identifiers

PMID: 33570627
DOI: 10.1182/bloodadvances.2020002981
PMCID: PMC7805315

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