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Article

Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein.

The Journal of biological chemistry - 1 Nov 2023

Tetenborg Stephan, Liss Viktoria, Breitsprecher Leonhard, Timonina Ksenia, Kotova Anna, Acevedo Harnecker Alejandra Jesús, Yuan Chunxu, Shihabeddin Eyad, Ariakia Fatemeh, Qin Guoting, Chengzhi Cai, Dedek Karin, Zoidl Georg, Hensel Michael, O'Brien John

Abstract excerpt

The intracellular domains of connexins are essential for the assembly of gap junctions. For connexin 36 (Cx36), the major neuronal connexin, it has been shown that a dysfunctional PDZ-binding motif interferes with electrical synapse formation. However, it is still unknown how this motif coordinates the transport of Cx36. In the present study, we characterize a phenotype of Cx36 mutants that lack a functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37742923
DOI: 10.1016/j.jbc.2023.105282
PMCID: PMC10637963

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