Article

Chromobox 3 Assembles a Novel Epigenetic Complex Contributing to Cystathionine γ-lyase–mediated Protection Against Aortic Aneurysm/dissection

2025-09-03

Abstract excerpt

<title>Abstract</title> <p> Hydrogen sulfide (H₂S), generated by cystathionine γ-lyase (CSE), exerts protective effects against aortic aneurysm/dissection (AAD). Proteoglycans, major extracellular matrix (ECM) components synthesized by vascular smooth muscle cells (VSMCs), preserve aortic wall integrity but also contribute to AAD pathogenesis. The mechanisms linking VSMC-derived CSE/H₂S to proteoglycan regulatio...

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Literature Corpus work: 9e8820d3-dfaa-5933-97ef-0b4a9c2ee196
DOI: 10.21203/rs.3.rs-7423522/v1

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