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Article

Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections.

Circulation - 19 Sept 2023

Chakraborty Abhijit, Li Yanming, Zhang Chen, Li Yang, Rebello Kimberly R, Li Shengyu, Xu Samantha, Vasquez Hernan G, Zhang Lin, Luo Wei, Wang Guangyu, Chen Kaifu, Coselli Joseph S, LeMaire Scott A, Shen Ying H

Abstract excerpt

BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC phenotypes in AAD tissues and the mechanisms driving SMC phenotypic alterations remain to be identified. METHODS: We examined the transcriptomic and epigenomic dynamics of aortic SMC phenotypic changes in mice with angiotensin II-induced AAD by using...

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Share to Aortic Aneurysm
Share to Aortic Aneurysm, Thoracic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Dissection

Share to Cells, Cultured

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Share to Epigenesis, Genetic

Share to Epigenomics

Share to Myocytes, Smooth Muscle

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Identifiers

PMID: 37555319
DOI: 10.1161/CIRCULATIONAHA.123.063332
PMCID: PMC10529114

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