Article

Cellular-Resolution Spatial Transcriptomics Reveals Laminar VSMC Phenotypic Remodeling and a Hypoxic Medial Core in Human Thoracic Aortic Dissection

2026-07-18

Abstract excerpt

Sporadic ascending aortic dissection (AAD) carries high short-term mortality and long-term morbidity. Hypertension is the predominant risk factor, yet no established tools identify patients at imminent risk. Although medial vulnerability likely contributes to dissection in heritable aortopathies, AAD predominantly understood as a luminal breach followed by false-lumen propagation, with comparatively less emphasis...

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Literature Corpus work: debe253f-ba69-52fb-8b59-cbacd3d74d07
DOI: 10.64898/2026.07.13.738344

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