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Article

Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption.

Scientific reports - 1 Jul 2021

Shiba Shunsuke, Nakamoto Nobuhiro, Chu Po-Sung, Ojiro Keisuke, Taniki Nobuhito, Yamaguchi Akihiro, Morikawa Rei, Katayama Tadashi, Yoshida Aya, Aoki Ryo, Teratani Toshiaki, Suzuki Takahiro, Miyamoto Takeshi, Hara Sachiko, Yokoyama Akira, Kanai Takanori

Abstract excerpt

Increased intestinal permeability and hepatic macrophage activation by endotoxins are involved in alcohol-induced liver injury pathogenesis. Long-term alcohol exposure conversely induces endotoxin immune tolerance; however, the precise mechanism and reversibility are unclear. Seventy-two alcohol-dependent patients with alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Cells, Cultured
Share to Liver Cirrhosis, Alcoholic
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Source

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Identifiers

PMID: 34211048
DOI: 10.1038/s41598-021-93086-y
PMCID: PMC8249592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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