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<i>APC</i> and <i>P53</i> mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

2022-07-27

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally, with the majority of cases initiated by inactivation of the APC tumor suppressor. This results in the constitutive transcriptional activation of the canonical WNT signal transduction pathway effector β-Catenin, along with induction of WNT feedback inhibitors, including the extracellular palmitoleoyl-protein carboxylesterase NOTUM. Here,...

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Literature Corpus work
9e648b0f-4f5a-5f12-b31c-cb5c240eca38
DOI
10.1101/2022.07.26.501557
Open publication

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<i>APC</i> and <i>P53</i> mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancerDOI 10.1101/2022.07.26.501557
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