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Article

APC and P53 mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer.

Gut - 24 Nov 2023

Tian Yuhua, Wang Xin, Cramer Zvi, Rhoades Joshua, Estep Katrina N, Ma Xianghui, Adams-Tzivelekidis Stephanie, Katona Bryson W, Johnson F Brad, Yu Zhengquan, Blanco M Andres, Lengner Christopher J, Li Ning

Abstract excerpt

OBJECTIVE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with the majority of cases initiated by inactivation of the APC tumour suppressor. This results in the constitutive activation of canonical WNT pathway transcriptional effector ß-catenin, along with induction of WNT feedback inhibitors, including the extracellular palmitoleoyl-protein carboxylesterase NOTUM which antagonises WNT-FZD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37591698
DOI: 10.1136/gutjnl-2022-329140
PMCID: PMC10715527

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