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Article

Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention

25 Mar 2024

Abstract excerpt

Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC , a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the...

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PMID: 38590663
DOI: 10.3389/fonc.2024.1343061

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