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Article

Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer

10 Aug 2022

Abstract excerpt

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect the circadian clock. We find that both genetic disruption and environmental disruption of the circadian clock accelerate Apc- driven CRC...

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PMID: 35947664
DOI: 10.1126/sciadv.abo2389

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