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p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer

26 Apr 2025

Abstract excerpt

Incidence of colorectal cancer (CRC) is increasing likely due to different mechanisms driving initiation and progression. The initial model proposed by Fearon and Vogelstein posits it as a multi-hit neoplasia, originating from adenomatous-polyps induced by WNT activation, ultimately progressing to aggressiveness through p53 loss. Integrating human data with mouse genetics, we redefine this paradigm, highlighting...

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PMID: 40287431
DOI: 10.1038/s41467-025-59282-4

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