Article
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Nature - 1 Jun 2021
Flanagan Dustin J, Pentinmikko Nalle, Luopajärvi Kalle, Willis Nicky J, Gilroy Kathryn, Raven Alexander P, Mcgarry Lynn, Englund Johanna I, Webb Anna T, Scharaw Sandra, Nasreddin Nadia, Hodder Michael C, Ridgway Rachel A, Minnee Emma, Sphyris Nathalie, Gilchrist Ella, Najumudeen Arafath K, Romagnolo Beatrice, Perret Christine, Williams Ann C, Clevers Hans, Nummela Pirjo, Lähde Marianne, Alitalo Kari, Hietakangas Ville, Hedley Ann, Clark William, Nixon Colin, Kirschner Kristina, Jones E Yvonne, Ristimäki Ari, Leedham Simon J, Fish Paul V, Vincent Jean-Paul, Katajisto Pekka, Sansom Owen J
Abstract excerpt
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling1, but reduced secretion of WNT ligands increases the ability of Apc-mutant intestinal stem cells to colonize a crypt (known as fixation)2. Here we investigated how Apc-mutant cells gain a clonal advantage over wild-type...
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