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Article

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Science translational medicine - 19 Oct 2016

Zhang Lu, Theodoropoulos Panayotis C, Eskiocak Ugur, Wang Wentian, Moon Young-Ah, Posner Bruce, Williams Noelle S, Wright Woodring E, Kim Sang Bum, Nijhawan Deepak, De Brabander Jef K, Shay Jerry W

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) gene are common in colorectal cancer (CRC), and more than 90% of those mutations generate stable truncated gene products. We describe a chemical screen using normal human colonic epithelial cells (HCECs) and a series of oncogenically progressed HCECs containing a truncated APC protein. With this screen, we identified a small molecule, TASIN-1 (truncated APC...

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Identifiers

PMID: 27798265
DOI: 10.1126/scitranslmed.aaf8127
PMCID: PMC7262871

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APC

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