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Article

Diet therapy abates mutant APC and KRas effects by reshaping plasma membrane cholesterol nanodomains.

Biophysical journal - 4 Feb 2025

Kim Eunjoo, Erazo-Oliveras Alfredo, Muñoz-Vega Mónica, Fuentes Natividad R, Salinas Michael L, George Miranda J, Zoh Roger S, Hensel Martha E, Patil Bhimanagouda S, Ivanov Ivan, Turner Nancy D, Chapkin Robert S

Abstract excerpt

Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the link between cholesterol homeostasis and mutant APC-KRas-associated colorectal tumorigenesis remains to be established. Thus, we investigated the impact of Apc-Kras on 1) colonocyte plasma membrane cholesterol homeostasis, order, and receptor nanoclustering, 2) colonocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39709523
DOI: 10.1016/j.bpj.2024.12.020
PMCID: PMC11866957

Genes

APC
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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