Article
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Nature metabolism - 1 Aug 2023
Vande Voorde Johan, Steven Rory T, Najumudeen Arafath K, Ford Catriona A, Dexter Alex, Gonzalez-Fernandez Ariadna, Nikula Chelsea J, Xiang Yuchen, Ford Lauren, Maneta Stavrakaki Stefania, Gilroy Kathryn, Zeiger Lucas B, Pennel Kathryn, Hatthakarnkul Phimmada, Elia Efstathios A, Nasif Ammar, Murta Teresa, Manoli Eftychios, Mason Sam, Gillespie Michael, Lannagan Tamsin R M, Vlahov Nikola, Ridgway Rachel A, Nixon Colin, Raven Alexander, Mills Megan, Athineos Dimitris, Kanellos Georgios, Nourse Craig, Gay David M, Hughes Mark, Burton Amy, Yan Bin, Sellers Katherine, Wu Vincen, De Ridder Kobe, Shokry Engy, Huerta Uribe Alejandro, Clark William, Clark Graeme, Kirschner Kristina, Thienpont Bernard, Li Vivian S W, Maddocks Oliver D K, Barry Simon T, Goodwin Richard J A, Kinross James, Edwards Joanne, Yuneva Mariia O, Sumpton David, Takats Zoltan, Campbell Andrew D, Bunch Josephine, Sansom Owen J
Abstract excerpt
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models, and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine. We show that untargeted metabolic profiling can be...
Read the complete abstract on PubMed